Impact Proteomics Awarded $1M Phase II SBIR grant from the National Science Foundation for development of ProMTag sample preparation technology

Impact Proteomics, LLC has been awarded a National Science Foundation (NSF) Phase II Small Business Innovation Research (SBIR) grant for $1M to conduct research and development (R&D) work to continue their work developing sample preparation tools using their novel reversible click chemistry technology known as ProMTag.

Impact Proteomics’ ProMTag technology utilizes chemistry on the surface of proteins to capture and cleanup protein samples before analysis. This novel approach to sample preparation is fast, high yield, works for both intact proteins and protein digests, and is compatible with the most popular analytical methods.  This technology has the ability to accelerate both fundamental and clinical research and ensure the production of clear, high-quality data.

Impact Proteomics presents their Universal Protein Extraction and Cleanup Kit at AlphaLab Gear’s Demo Day

“NSF is proud to support the technology of the future by thinking beyond incremental developments and funding the most creative, impactful ideas across all markets and areas of science and engineering,” said Andrea Belz, Division Director of the Division of Industrial Innovation and Partnerships at NSF. “With the support of our research funds, any deep technology startup or small business can guide basic science into meaningful solutions that address tremendous needs.”

Once a small business is awarded a Phase I SBIR/STTR grant (up to $256,000), it becomes eligible to apply for a Phase II (up to $1,000,000). Small businesses with Phase II funding are eligible to receive up to $500,000 in additional matching funds with qualifying third-party investment or sales.

“The funding received from the Phase II SBIR will be used for further development of our ProMTag technology and sample  preparation tools and an expansion into multi-omic applications.” said Amber Lucas, cofounder and Chief Executive Officer of Impact Proteomics. “What makes ProMTag so special is its ability to chemically separate proteins from other biological materials without damaging the other biological materials in the process.  That means other biomolecules like DNA, RNA, metabolites, etc. can also be purified from the same starting sample, allowing analysis using multiple -omics technologies and better reproducibility across data sets.”

NSF accepts Phase I proposals from small businesses at any time. Small businesses with innovative science and technology solutions, and commercial potential are encouraged to apply. All proposals submitted to the NSF SBIR/STTR program, also known as America’s Seed Fund powered by NSF, undergo a rigorous merit-based review process.

To learn more about the ProMTag technology and what makes it so exciting, check out how it works and why you should choose Impact Proteomics for your sample preparation tool set.

To learn more about America’s Seed Fund powered by NSF, visit:


About the National Science Foundation’s Small Business Programs: America’s Seed Fund powered by NSF awards $200 million annually to startups and small businesses, transforming scientific discovery into products and services with commercial and societal impact. Startups working across almost all areas of science and technology can receive up to $2 million in funding to support research and development (R&D), helping de-risk technology for commercial success. America’s Seed Fund is congressionally mandated through the Small Business Innovation Research (SBIR) program. The NSF is an independent federal agency with a budget of about $8.5 billion that supports fundamental research and education across all fields of science and engineering.